Fresh analysis indicates that people who stop using popular slimming jabs like semaglutide or tirzepatide can put back on reduced body mass at a significantly accelerated pace than those who end conventional diet and exercise regimens.
Findings released in a prominent medical journal demonstrates that while obese people frequently drop about a fifth of their body weight while using the jabs, the mass returns at an average rate of nearly a kilo each month once they quit.
"People purchasing such drugs should be cognizant of the danger of fast rebound weight gain when the therapy is stopped," cautioned expert Dr. Susan Jebb.
That rate of recovery suggests a reversion to pre-treatment mass within about a year and a half.
Weighing Therapies
The research, which examined 37 of trials involving thousands of participants, contrasted the outcomes of the injectable medications with other pills.
Scientists note that people who shed pounds through diet and exercise typically see a less rapid creep back—approximately 0.1 kg a month—once they finish.
The Reason for the Rapid Rebound
Nutrition scientists suggest the mechanism of the injections is key to understanding the accelerated rebound.
These medications copy a body's own chemical called GLP-1, which controls hunger.
"Artificially providing the hormone levels several times higher than normal might result in the body to produce less of its endogenous GLP-1, and may also lessen responsiveness to its effects," noted Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication results in hunger is no longer kept in check, making binge eating far more likely."
An Ongoing Issue?
Medical guidelines suggest the jabs for individuals with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
A number of clinicians argue that, considering the high risk of weight regain, the treatment should be considered life-long.
This view is reinforced by drug manufacturers, who note that the findings "underscore the long-term nature of obesity," similar to managing diseases like hypertension.
User Testimonies
People who have stopped the jabs report a sudden return of hunger.
"It felt as if a trigger activating and you're instantly starving," said an individual.
This difficulty is compounded if patients have not adopted sustainable lifestyle or habit changes during therapy.
Widespread Interest
Survey data show that millions of adults in the UK have tried these injections in the past year, with demand remaining high.
- Use is greater among women compared to men.
- The middle-aged age group shows the highest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Ultimately, experts emphasize that while GLP-1 drugs are powerful tools for shedding pounds, they are not a standalone cure and lasting health benefits hinges on combined lifestyle changes.
